Genome-wide CRISPR screens identify ferroptosis as a novel therapeutic vulnerability in acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most frequent cancer diagnosed in children. Despite the great progress achieved over the last 40 years, with cure rates now exceeding 85%, refractory or relapsed ALL still exhibit a dismal prognosis. This poor outcome reflects the lack of treatment options s...

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Detalles Bibliográficos
Autores principales: Lalonde, Marie-Eve, Sasseville, Marc, Gélinas, Anne-Marie, Milanese, Jean-Sébastien, Béland, Kathie, Drouin, Simon, Haddad, Elie, Marcotte, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890019/
https://www.ncbi.nlm.nih.gov/pubmed/36134452
http://dx.doi.org/10.3324/haematol.2022.280786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890019/
https://www.ncbi.nlm.nih.gov/pubmed/36134452
http://dx.doi.org/10.3324/haematol.2022.280786

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