Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas

Histone methylation-modifiers, such as EZH2 and KMT2D, are recurrently altered in B-cell lymphomas. To comprehensively describe the landscape of alterations affecting genes encoding histone methylation-modifiers in lymphomagenesis we investigated whole genome and transcriptome data of 186 mature B-c...

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Detalles Bibliográficos
Autores principales: López, Cristina, Schleussner, Nikolai, Bernhart, Stephan H., Kleinheinz, Kortine, Sungalee, Stephanie, Sczakiel, Henrike L., Kretzmer, Helene, Toprak, Umut H., Glaser, Selina, Wagener, Rabea, Ammerpohl, Ole, Bens, Susanne, Giefing, Maciej, González Sánchez, Juan C., Apic, Gordana, Hübschmann, Daniel, Janz, Martin, Kreuz, Markus, Mottok, Anja, Müller, Judith M., Seufert, Julian, Hoffmann, Steve, Korbel, Jan O., Russell, Robert B., Schüle, Roland, Trümper, Lorenz, Klapper, Wolfram, Radlwimmer, Bernhard, Lichter, Peter, Küppers, Ralf, Schlesner, Matthias, Mathas, Stephan, Siebert, Reiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Non-Hodgkin Lymphoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890021/
https://www.ncbi.nlm.nih.gov/pubmed/35522148
http://dx.doi.org/10.3324/haematol.2021.280005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890021/
https://www.ncbi.nlm.nih.gov/pubmed/35522148
http://dx.doi.org/10.3324/haematol.2021.280005

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