BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is an intractable disease and most cases harbor genetic alterations that activate JAK or ABL signaling. The commonest subtype of Ph-like ALL exhibits a CRLF2 gene rearrangement that brings about JAK1/2-STAT5 pathway activation....

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Detalles Bibliográficos
Autores principales: Tsuzuki, Shinobu, Yasuda, Takahiko, Goto, Hiroaki, Maeda, Naoko, Akahane, Koshi, Inukai, Takeshi, Yamamoto, Hideyuki, Karnan, Sivasundaram, Ota, Akinobu, Hyodo, Toshinori, Konishi, Hiroyuki, Hosokawa, Yoshitaka, Kiyoi, Hitoshi, Hayakawa, Fumihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Lymphoblastic Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890033/
https://www.ncbi.nlm.nih.gov/pubmed/36005560
http://dx.doi.org/10.3324/haematol.2022.280879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890033/
https://www.ncbi.nlm.nih.gov/pubmed/36005560
http://dx.doi.org/10.3324/haematol.2022.280879

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