Cargando…

Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR

Severe acute pancreatitis (SAP) is a lethal gastrointestinal disorder, yet no specific and effective treatment is available. Its pathogenesis involves inflammatory cascade, oxidative stress, and autophagy dysfunction. Xanthohumol (Xn) displays various medicinal properties, including anti-inflammatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huangfu, Yaru, Yu, Xiuxian, Wan, Chengyu, Zhu, Yuda, Wei, Zeliang, Li, Fan, Wang, Yilan, Zhang, Kun, Li, Shiyi, Dong, Yuman, Li, Yangying, Niu, Hai, Xin, Guang, Huang, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890064/ https://www.ncbi.nlm.nih.gov/pubmed/36744265 http://dx.doi.org/10.3389/fphar.2023.1105726

Ejemplares similares

Drug D, a Diosgenin Derive, Inhibits L-Arginine-Induced Acute Pancreatitis through Meditating GSDMD in the Endoplasmic Reticulum via the TXNIP/HIF-1α Pathway
por: Zhang, Cuicui, et al.
Publicado: (2022)

PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway
por: Li, Yulong, et al.
Publicado: (2022)

Xanthohumol Inhibits TGF-β1-Induced Cardiac Fibroblasts Activation via Mediating PTEN/Akt/mTOR Signaling Pathway
por: Jiang, Chuanhao, et al.
Publicado: (2020)

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling
por: Tang, Yanghua, et al.
Publicado: (2021)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway
por: Zhu, Zhongsheng, et al.
Publicado: (2021)

Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy
por: Wu, Yuanyuan, et al.
Publicado: (2020)

Esomeprazole Alleviates Cisplatin Resistance by Inhibiting the AKT/mTOR Pathway in Ovarian Cancer Cells
por: Duan, Jingya, et al.
Publicado: (2023)

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway
por: Li, Xiao-yu, et al.
Publicado: (2017)

Dihydroartemisinin Induces Endothelial Cell Autophagy through Suppression of the Akt/mTOR Pathway
por: Liu, Jing, et al.
Publicado: (2019)

RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway
por: Jiao, Yuheng, et al.
Publicado: (2022)

Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
por: Qiao, Hong, et al.
Publicado: (2018)

Mingmu Xiaomeng Tablets Restore Autophagy and Alleviate Diabetic Retinopathy by Inhibiting PI3K/Akt/mTOR Signaling
por: Fang, Yuwei, et al.
Publicado: (2021)

BMSC-Derived Exosomes Alleviate Intervertebral Disc Degeneration by Modulating AKT/mTOR-Mediated Autophagy of Nucleus Pulposus Cells
por: Xiao, Quan, et al.
Publicado: (2022)

Ozone oil promotes wound healing by increasing the migration of fibroblasts via PI3K/Akt/mTOR signaling pathway
por: Xiao, Weirong, et al.
Publicado: (2017)

Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
por: Liu, Nanjing, et al.
Publicado: (2022)

Hyperbaric oxygen relieves neuropathic pain through AKT/TSC2/mTOR pathway activity to induce autophagy
por: Liu, Yong-Da, et al.
Publicado: (2019)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Autophagy activation promotes bevacizumab resistance in glioblastoma by suppressing Akt/mTOR signaling pathway
por: Huang, He, et al.
Publicado: (2018)

The Roles of Autophagy, Mitophagy, and the Akt/mTOR Pathway in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps
por: Wang, Chen, et al.
Publicado: (2022)

Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway
por: Zheng, Xiangjin, et al.
Publicado: (2021)

Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells
por: Li, Gaopan, et al.
Publicado: (2021)

YAP manipulates proliferation via PTEN/AKT/mTOR-mediated autophagy in lung adenocarcinomas
por: Xu, Wei, et al.
Publicado: (2021)

Autophagy Triggered by Oxidative Stress Appears to Be Mediated by the AKT/mTOR Signaling Pathway in the Liver of Sleep-Deprived Rats
por: Li, Yongmei, et al.
Publicado: (2020)

Siniperca chuatsi rhabdovirus (SCRV) induces autophagy via PI3K/Akt-mTOR pathway in CPB cells
por: Fu, Xiaozhe, et al.
Publicado: (2020)

Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition
por: Lakhani, Ronak, et al.
Publicado: (2014)

Sodium cantharidate promotes autophagy in breast cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
por: Pang, Jin-Long, et al.
Publicado: (2022)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Downregulation of AKT/mTOR signaling pathway for Salmonella-mediated autophagy in human anaplastic thyroid cancer
por: Wu, Li-Hsien, et al.
Publicado: (2022)

Autophagy of macrophages is regulated by PI3k/Akt/mTOR signalling in the development of diabetic encephalopathy
por: Wang, Beiyun, et al.
Publicado: (2018)

Arctigenin Inhibits Glioblastoma Proliferation through the AKT/mTOR Pathway and Induces Autophagy
por: Jiang, Yong'an, et al.
Publicado: (2020)

Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells
por: Gao, Likun, et al.
Publicado: (2019)

PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin-3-gallate in ovarian cancer
por: Qin, Jianli, et al.
Publicado: (2020)

Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression
por: Gong, Xuelian, et al.
Publicado: (2021)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Akt/mTOR-Mediated Autophagy Confers Resistance To BET Inhibitor JQ1 In Ovarian Cancer
por: Luan, Wenqing, et al.
Publicado: (2019)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Calcium Dobesilate Restores Autophagy by Inhibiting the VEGF/PI3K/AKT/mTOR Signaling Pathway
por: Wang, Yue, et al.
Publicado: (2019)

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis
por: Li, Ming-yong, et al.
Publicado: (2019)

Qi-Li-Qiang-Xin Alleviates Isoproterenol-Induced Myocardial Injury by Inhibiting Excessive Autophagy via Activating AKT/mTOR Pathway
por: Fan, Cailian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s9rr6ikrn2uba0sbgiitd27lor