Cargando…

Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination

Di‐monoubiquitination of the FANCI‐FANCD2 (ID2) complex is a central and crucial step for the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 ubiquitination precedes FANCI ubiquitination, FANCD2 is also deubiquitinated at a faster rate than FANCI, which can result...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lemonidis, Kimon, Rennie, Martin L, Arkinson, Connor, Chaugule, Viduth K, Clarke, Mairi, Streetley, James, Walden, Helen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890228/ https://www.ncbi.nlm.nih.gov/pubmed/36385258 http://dx.doi.org/10.15252/embj.2022111898

Ejemplares similares

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
por: Rennie, Martin L, et al.
Publicado: (2020)

Allosteric mechanism for site-specific ubiquitination of FANCD2
por: Chaugule, Viduth K., et al.
Publicado: (2019)

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
por: Arkinson, Connor, et al.
Publicado: (2018)

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
por: Rennie, Martin L., et al.
Publicado: (2022)

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening
por: Morreale, Francesca E., et al.
Publicado: (2017)

Specificity and disease in the ubiquitin system
por: Chaugule, Viduth K., et al.
Publicado: (2016)

Structural insight into FANCI–FANCD2 monoubiquitination
por: Li, Landing, et al.
Publicado: (2020)

ATR-Mediated FANCI Phosphorylation Regulates Both Ubiquitination and Deubiquitination of FANCD2
por: Tan, Winnie, et al.
Publicado: (2020)

Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation
por: Burchell, Lynn, et al.
Publicado: (2012)

Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA
por: Longerich, Simonne, et al.
Publicado: (2014)

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
por: Liang, Chih-Chao, et al.
Publicado: (2016)

A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2
por: Dubois, Emilie L, et al.
Publicado: (2019)

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI
por: Sato, Koichi, et al.
Publicado: (2012)

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination
por: Liang, Zhuobin, et al.
Publicado: (2019)

FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
por: Alcón, Pablo, et al.
Publicado: (2020)

Coordinate Nuclear Targeting of the FANCD2 and FANCI Proteins via a FANCD2 Nuclear Localization Signal
por: Boisvert, Rebecca A., et al.
Publicado: (2013)

FANCI Protein Binds to DNA and Interacts with FANCD2 to Recognize Branched Structures
por: Yuan, Fenghua, et al.
Publicado: (2009)

The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
por: Rajendra, Eeson, et al.
Publicado: (2014)

The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2
por: Swuec, Paolo, et al.
Publicado: (2016)

Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage
por: Lopez-Martinez, David, et al.
Publicado: (2019)

Defective FANCI Binding by a Fanconi Anemia-Related FANCD2 Mutant
por: Sato, Koichi, et al.
Publicado: (2014)

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements
por: Morreale, Francesca E., et al.
Publicado: (2017)

Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3
por: Alpi, Arno F., et al.
Publicado: (2016)

Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors
por: Moriel-Carretero, María, et al.
Publicado: (2017)

FANCD2 regulates BLM complex functions independently of FANCI to promote replication fork recovery
por: Chaudhury, Indrajit, et al.
Publicado: (2013)

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2
por: Castella, Maria, et al.
Publicado: (2015)

Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase
por: Sareen, Archana, et al.
Publicado: (2012)

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response
por: Thompson, Elizabeth L., et al.
Publicado: (2017)

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays
por: Tan, Winnie, et al.
Publicado: (2020)

FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end
por: Sato, Koichi, et al.
Publicado: (2016)

Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI
por: Sun, Siyuan, et al.
Publicado: (2020)

Parkin-phosphoubiquitin complex reveals a cryptic ubiquitin binding site required for RBR ligase activity
por: Kumar, Atul, et al.
Publicado: (2017)

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL
por: Miles, Jennifer A., et al.
Publicado: (2015)

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation
por: Clark, David W., et al.
Publicado: (2015)

Fancy & imagination
por: Brett, R. L.
Publicado: (1969)

Fancy Fees
Publicado: (1888)

Facts and Fancies
Publicado: (1897)

Facts and Fancies
Publicado: (1897)

Fact and fancy in neutrino physics
por: De Rújula, Alvaro, et al.
Publicado: (1973)

Fancy a ride?
por: Anaïs Schaeffer
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_on6sf8sjef1r38b9g6ptki77g5