Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms

Phospholipid extrusion by ABC subfamily A (ABCA) exporters is central to cellular physiology, although the specifics of the underlying substrate interactions and transport mechanisms remain poorly resolved at the molecular level. Here we report cryo‐EM structures of lipid‐embedded human ABCA7 in an...

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Detalles Bibliográficos
Autores principales: Le, Le Thi My, Thompson, James Robert, Dehghani‐Ghahnaviyeh, Sepehr, Pant, Shashank, Dang, Phuoc Xuan, French, Jarrod Bradley, Kanikeyo, Takahisa, Tajkhorshid, Emad, Alam, Amer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890230/
https://www.ncbi.nlm.nih.gov/pubmed/36484366
http://dx.doi.org/10.15252/embj.2022111065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890230/
https://www.ncbi.nlm.nih.gov/pubmed/36484366
http://dx.doi.org/10.15252/embj.2022111065

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