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Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms
Phospholipid extrusion by ABC subfamily A (ABCA) exporters is central to cellular physiology, although the specifics of the underlying substrate interactions and transport mechanisms remain poorly resolved at the molecular level. Here we report cryo‐EM structures of lipid‐embedded human ABCA7 in an...
Autores principales: | Le, Le Thi My, Thompson, James Robert, Dehghani‐Ghahnaviyeh, Sepehr, Pant, Shashank, Dang, Phuoc Xuan, French, Jarrod Bradley, Kanikeyo, Takahisa, Tajkhorshid, Emad, Alam, Amer |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890230/ https://www.ncbi.nlm.nih.gov/pubmed/36484366 http://dx.doi.org/10.15252/embj.2022111065 |
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