Altered Expression and In Vivo Activity of mGlu5 Variant a Receptors in the Striatum of BTBR Mice: Novel Insights Into the Pathophysiology of Adult Idiopathic Forms of Autism Spectrum Disorders

BACKGROUND: mGlu5 metabotropic glutamate receptors are considered as candidate drug targets in the treatment of “monogenic” forms of autism spectrum disorders (ASD), such as Fragile-X syndrome (FXS). However, despite promising preclinical data, clinical trials using mGlu5 receptor antagonists to tre...

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Detalles Bibliográficos
Autores principales: Matrisciano, Francesco, Locci, Valentina, Dong, Erbo, Nicoletti, Ferdinando, Guidotti, Alessandro, Grayson, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890299/
https://www.ncbi.nlm.nih.gov/pubmed/35139800
http://dx.doi.org/10.2174/1567202619999220209112609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890299/
https://www.ncbi.nlm.nih.gov/pubmed/35139800
http://dx.doi.org/10.2174/1567202619999220209112609

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