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Milk Fermented with Pediococcus acidilactici Strain BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in Diabetic Rats
This study evaluated the effects of milk fermented with Pediococcus acidilactici strain BE and Pediococcus pentosaceus strain M103 on diabetes in rats (Rattus norvegicus). The bacteria were separately used as starter cultures for milk fermentation, and the products were then fed to diabetic rats for...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Food Science of Animal Resources
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890364/ https://www.ncbi.nlm.nih.gov/pubmed/36789203 http://dx.doi.org/10.5851/kosfa.2022.e69 |
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author | Widodo, Widodo Kusumaningrum, Hanna Respati Putri Wihadmadyatami, Hevi Wicaksana, Anggi Lukman |
author_facet | Widodo, Widodo Kusumaningrum, Hanna Respati Putri Wihadmadyatami, Hevi Wicaksana, Anggi Lukman |
author_sort | Widodo, Widodo |
collection | PubMed |
description | This study evaluated the effects of milk fermented with Pediococcus acidilactici strain BE and Pediococcus pentosaceus strain M103 on diabetes in rats (Rattus norvegicus). The bacteria were separately used as starter cultures for milk fermentation, and the products were then fed to diabetic rats for 15 days. Blood glucose levels, immunohistochemical and histological indicators, lipid profiles, and total lactic acid bacterium counts were evaluated before and after treatment. The administration of milk fermented with P. acidilactici strain BE reduced blood glucose levels from 410.27±51.60 to 304.07±9.88 mg/dL (p<0.05), similar to the effects of metformin (from 382.30±13.39 mg/dL to 253.33±40.66 mg/dL, p<0.05). Increased insulin production was observed in diabetic rats fed milk fermented with P. acidilactici strain BE concomitant with an increased number and percentage area of immunoreactive beta-cells. The structure of insulin-producing beta-cells was improved in diabetic rats fed milk fermented with P. acidilactici strain BE or metformin (insulin receptor substrate scores of 5.33±0.94 and 3.5±0.5, respectively). This suggests that the administration of milk fermented with P. acidilactici BE potentially reduces blood glucose levels and improves pancreatic beta-cell function in diabetic rats. |
format | Online Article Text |
id | pubmed-9890364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Korean Society for Food Science of Animal Resources |
record_format | MEDLINE/PubMed |
spelling | pubmed-98903642023-02-13 Milk Fermented with Pediococcus acidilactici Strain BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in Diabetic Rats Widodo, Widodo Kusumaningrum, Hanna Respati Putri Wihadmadyatami, Hevi Wicaksana, Anggi Lukman Food Sci Anim Resour Article This study evaluated the effects of milk fermented with Pediococcus acidilactici strain BE and Pediococcus pentosaceus strain M103 on diabetes in rats (Rattus norvegicus). The bacteria were separately used as starter cultures for milk fermentation, and the products were then fed to diabetic rats for 15 days. Blood glucose levels, immunohistochemical and histological indicators, lipid profiles, and total lactic acid bacterium counts were evaluated before and after treatment. The administration of milk fermented with P. acidilactici strain BE reduced blood glucose levels from 410.27±51.60 to 304.07±9.88 mg/dL (p<0.05), similar to the effects of metformin (from 382.30±13.39 mg/dL to 253.33±40.66 mg/dL, p<0.05). Increased insulin production was observed in diabetic rats fed milk fermented with P. acidilactici strain BE concomitant with an increased number and percentage area of immunoreactive beta-cells. The structure of insulin-producing beta-cells was improved in diabetic rats fed milk fermented with P. acidilactici strain BE or metformin (insulin receptor substrate scores of 5.33±0.94 and 3.5±0.5, respectively). This suggests that the administration of milk fermented with P. acidilactici BE potentially reduces blood glucose levels and improves pancreatic beta-cell function in diabetic rats. Korean Society for Food Science of Animal Resources 2023-01 2023-01-01 /pmc/articles/PMC9890364/ /pubmed/36789203 http://dx.doi.org/10.5851/kosfa.2022.e69 Text en © Korean Society for Food Science of Animal Resources https://creativecommons.org/licenses/by-nc/3.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Widodo, Widodo Kusumaningrum, Hanna Respati Putri Wihadmadyatami, Hevi Wicaksana, Anggi Lukman Milk Fermented with Pediococcus acidilactici Strain BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in Diabetic Rats |
title | Milk Fermented with Pediococcus acidilactici Strain
BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in
Diabetic Rats |
title_full | Milk Fermented with Pediococcus acidilactici Strain
BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in
Diabetic Rats |
title_fullStr | Milk Fermented with Pediococcus acidilactici Strain
BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in
Diabetic Rats |
title_full_unstemmed | Milk Fermented with Pediococcus acidilactici Strain
BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in
Diabetic Rats |
title_short | Milk Fermented with Pediococcus acidilactici Strain
BE Improves High Blood Glucose Levels and Pancreatic Beta-Cell Function in
Diabetic Rats |
title_sort | milk fermented with pediococcus acidilactici strain
be improves high blood glucose levels and pancreatic beta-cell function in
diabetic rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890364/ https://www.ncbi.nlm.nih.gov/pubmed/36789203 http://dx.doi.org/10.5851/kosfa.2022.e69 |
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