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Pharmacological inhibition of FOXO1 promotes lymphatic valve growth in a congenital lymphedema mouse model
Mutations in many genes that regulate lymphatic valve development are associated with congenital lymphedema. Oscillatory shear stress (OSS) from lymph provides constant signals for the growth and maintenance of valve cells throughout life. The expression of valve-forming genes in lymphatic endotheli...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890395/ https://www.ncbi.nlm.nih.gov/pubmed/36742198 http://dx.doi.org/10.3389/fcell.2022.1024628 |