Small change for big improvement in the preparation of the key intermediate N(1), N(3)-disubstituted 1,3,5-triazone of ensitrelvir

In this study, the key intermediate N(1), N(3)-disubstituted 1,3,5-triazone of ensitrelvir fumaric acid, approved in Japan for the treatment of SARS-CoV-2 infection under the emergency regulatory approval system, was produced from S-ethylisothiourea hydrobromide and aminomethyl triazole with CDI by...

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Detalles Bibliográficos
Autores principales: Hu, Wei, Liu, Yuanchang, Zhang, Xiang, Zheng, Panpan, Yang, Feifei, Guo, Guangyang, Xie, Xin, Huang, Jiuzhong, Chen, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890673/
https://www.ncbi.nlm.nih.gov/pubmed/36756552
http://dx.doi.org/10.1039/d2ra07844a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890673/
https://www.ncbi.nlm.nih.gov/pubmed/36756552
http://dx.doi.org/10.1039/d2ra07844a

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