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Sunitinib efficacy with minimal toxicity in patient-derived retinoblastoma organoids

BACKGROUND: Recurrence of retinoblastoma (RB) following chemoreduction is common and is often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors are resistant to even local administration of maximum feasible drug dosages, or effective tumor control and globe preserva...

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Detalles Bibliográficos
Autores principales: Srimongkol, Atthapol, Laosillapacharoen, Natanan, Saengwimol, Duangporn, Chaitankar, Vijender, Rojanaporn, Duangnate, Thanomchard, Thanastha, Borwornpinyo, Suparerk, Hongeng, Suradej, Kaewkhaw, Rossukon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890748/
https://www.ncbi.nlm.nih.gov/pubmed/36726110
http://dx.doi.org/10.1186/s13046-023-02608-1