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Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis
Alkali-metal salts of 9,10-dimethyl-9,10-dihydro-9,10-diboraanthrancene (M(2)[DBA-Me(2)]; M(+) = Li(+), Na(+), K(+)) activate the H–B bond of pinacolborane (HBpin) in THF already at room temperature. For M(+) = Na(+), K(+), the addition products M(2)[4] are formed, which contain one new H–B and one...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890859/ https://www.ncbi.nlm.nih.gov/pubmed/36755708 http://dx.doi.org/10.1039/d2sc05518j |
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author | Prey, Sven E. Herok, Christoph Fantuzzi, Felipe Bolte, Michael Lerner, Hans-Wolfram Engels, Bernd Wagner, Matthias |
author_facet | Prey, Sven E. Herok, Christoph Fantuzzi, Felipe Bolte, Michael Lerner, Hans-Wolfram Engels, Bernd Wagner, Matthias |
author_sort | Prey, Sven E. |
collection | PubMed |
description | Alkali-metal salts of 9,10-dimethyl-9,10-dihydro-9,10-diboraanthrancene (M(2)[DBA-Me(2)]; M(+) = Li(+), Na(+), K(+)) activate the H–B bond of pinacolborane (HBpin) in THF already at room temperature. For M(+) = Na(+), K(+), the addition products M(2)[4] are formed, which contain one new H–B and one new B–Bpin bond; for M(+) = Li(+), the H(−) ion is instantaneously transferred from the DBA-Me(2) unit to another equivalent of HBpin to afford Li[5]. Although Li[5] might commonly be considered a [Bpin](−) adduct of neutral DBA-Me(2), it donates a [Bpin](+) cation to Li[SiPh(3)], generating the silyl borane Ph(3)Si–Bpin; Li(2)[DBA-Me(2)] with an aromatic central B(2)C(4) ring acts as the leaving group. Furthermore, Li(2)[DBA-Me(2)] catalyzes the hydroboration of various unsaturated substrates with HBpin in THF. Quantum-chemical calculations complemented by in situ NMR spectroscopy revealed two different mechanistic scenarios that are governed by the steric demand of the substrate used: in the case of the bulky Ph(H)C[double bond, length as m-dash]NtBu, the reaction requires elevated temperatures of 100 °C, starts with H–Bpin activation which subsequently generates Li[BH(4)], so that the mechanism eventually turns into “hidden borohydride catalysis”. Ph(H)C[double bond, length as m-dash]NPh, Ph(2)C[double bond, length as m-dash]O, Ph(2)C[double bond, length as m-dash]CH(2), and iPrN[double bond, length as m-dash]C[double bond, length as m-dash]NiPr undergo hydroboration already at room temperature. Here, the active hydroboration catalyst is the [4 + 2] cycloadduct between the respective substrate and Li(2)[DBA-Me(2)]: in the key step, attack of HBpin on the bridging unit opens the bicyclo[2.2.2]octadiene scaffold and gives the activated HBpin adduct of the Lewis-basic moiety that was previously coordinated to the DBA-B atom. |
format | Online Article Text |
id | pubmed-9890859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-98908592023-02-07 Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis Prey, Sven E. Herok, Christoph Fantuzzi, Felipe Bolte, Michael Lerner, Hans-Wolfram Engels, Bernd Wagner, Matthias Chem Sci Chemistry Alkali-metal salts of 9,10-dimethyl-9,10-dihydro-9,10-diboraanthrancene (M(2)[DBA-Me(2)]; M(+) = Li(+), Na(+), K(+)) activate the H–B bond of pinacolborane (HBpin) in THF already at room temperature. For M(+) = Na(+), K(+), the addition products M(2)[4] are formed, which contain one new H–B and one new B–Bpin bond; for M(+) = Li(+), the H(−) ion is instantaneously transferred from the DBA-Me(2) unit to another equivalent of HBpin to afford Li[5]. Although Li[5] might commonly be considered a [Bpin](−) adduct of neutral DBA-Me(2), it donates a [Bpin](+) cation to Li[SiPh(3)], generating the silyl borane Ph(3)Si–Bpin; Li(2)[DBA-Me(2)] with an aromatic central B(2)C(4) ring acts as the leaving group. Furthermore, Li(2)[DBA-Me(2)] catalyzes the hydroboration of various unsaturated substrates with HBpin in THF. Quantum-chemical calculations complemented by in situ NMR spectroscopy revealed two different mechanistic scenarios that are governed by the steric demand of the substrate used: in the case of the bulky Ph(H)C[double bond, length as m-dash]NtBu, the reaction requires elevated temperatures of 100 °C, starts with H–Bpin activation which subsequently generates Li[BH(4)], so that the mechanism eventually turns into “hidden borohydride catalysis”. Ph(H)C[double bond, length as m-dash]NPh, Ph(2)C[double bond, length as m-dash]O, Ph(2)C[double bond, length as m-dash]CH(2), and iPrN[double bond, length as m-dash]C[double bond, length as m-dash]NiPr undergo hydroboration already at room temperature. Here, the active hydroboration catalyst is the [4 + 2] cycloadduct between the respective substrate and Li(2)[DBA-Me(2)]: in the key step, attack of HBpin on the bridging unit opens the bicyclo[2.2.2]octadiene scaffold and gives the activated HBpin adduct of the Lewis-basic moiety that was previously coordinated to the DBA-B atom. The Royal Society of Chemistry 2022-12-05 /pmc/articles/PMC9890859/ /pubmed/36755708 http://dx.doi.org/10.1039/d2sc05518j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Prey, Sven E. Herok, Christoph Fantuzzi, Felipe Bolte, Michael Lerner, Hans-Wolfram Engels, Bernd Wagner, Matthias Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis |
title | Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis |
title_full | Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis |
title_fullStr | Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis |
title_full_unstemmed | Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis |
title_short | Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis |
title_sort | multifaceted behavior of a doubly reduced arylborane in b–h-bond activation and hydroboration catalysis |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9890859/ https://www.ncbi.nlm.nih.gov/pubmed/36755708 http://dx.doi.org/10.1039/d2sc05518j |
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