How a single mutation alters the protein structure: a simulation investigation on protein tyrosine phosphatase SHP2

Protein tyrosine phosphatase SHP2 is a key regulator modulating several signaling pathways. The oncogenic mutation E76K in SHP2 releases the enzyme from an autoinhibited, closed conformation into an active, open conformation. Here, we investigated the conformational dynamics of SHP2 and the effect o...

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Detalles Bibliográficos
Autores principales: Hou, Yingnan, Lu, Xiaoli, Xu, Ziyao, Qu, Jiarun, Huang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891203/
https://www.ncbi.nlm.nih.gov/pubmed/36760301
http://dx.doi.org/10.1039/d2ra07472a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891203/
https://www.ncbi.nlm.nih.gov/pubmed/36760301
http://dx.doi.org/10.1039/d2ra07472a

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