PRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stability

Tumor relapse is the major cause of treatment failure in childhood acute lymphoblastic leukemia (ALL), yet the underlying mechanisms are still elusive. Here, we demonstrate that phosphoribosyl pyrophosphate synthetase 2 (PRPS2) mutations drive ALL relapse through influencing PRPS1/2 hexamer stabilit...

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Detalles Bibliográficos
Autores principales: Song, Lili, Li, Peifeng, Sun, Huiying, Ding, Lixia, Wang, Jing, Li, Benshang, Zhou, Bin-Bing S., Feng, Haizhong, Li, Yanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891442/
https://www.ncbi.nlm.nih.gov/pubmed/36742181
http://dx.doi.org/10.1097/BS9.0000000000000139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891442/
https://www.ncbi.nlm.nih.gov/pubmed/36742181
http://dx.doi.org/10.1097/BS9.0000000000000139

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