Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

Alzheimer’s disease and related tauopathies are characterized by the pathogenic misfolding and aggregation of the microtubule-associated protein tau. Understanding how endogenous chaperones modulate tau misfolding could guide future therapies. Here, we show that the immunophilin FKBP12, the 12-kDa F...

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Detalles Bibliográficos
Autores principales: Jiang, Lulu, Chakraborty, Pijush, Zhang, Lushuang, Wong, Melissa, Hill, Shannon E., Webber, Chelsea Joy, Libera, Jenna, Blair, Laura J., Wolozin, Benjamin, Zweckstetter, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891691/
https://www.ncbi.nlm.nih.gov/pubmed/36724228
http://dx.doi.org/10.1126/sciadv.add9789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891691/
https://www.ncbi.nlm.nih.gov/pubmed/36724228
http://dx.doi.org/10.1126/sciadv.add9789

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