RNA binding protein DDX5 restricts RORγt(+) T(reg) suppressor function to promote intestine inflammation

Retinoid-related orphan receptor (RAR) gamma (RORγt)–expressing regulatory T cells (RORγt(+) T(regs)) play pivotal roles in preventing T cell hyperactivation and maintaining tissue homeostasis, in part by secreting the anti-inflammation cytokine interleukin-10 (IL-10). Here, we report that hypoxia-i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Shengyun, Yang, Qiyuan, Chen, Nicholas, Zheng, Anna, Abbasi, Nazia, Wang, Gaowei, Patel, Parth R., Cho, Benjamin S., Yee, Brian A., Zhang, Lunfeng, Chu, Hiutung, Evans, Sylvia M., Yeo, Gene W., Zheng, Ye, Huang, Wendy Jia Men
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891705/
https://www.ncbi.nlm.nih.gov/pubmed/36724232
http://dx.doi.org/10.1126/sciadv.add6165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891705/
https://www.ncbi.nlm.nih.gov/pubmed/36724232
http://dx.doi.org/10.1126/sciadv.add6165

Ejemplares similares