Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell fates being driven by signal intensity. We have used primary hepatocy...

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Detalles Bibliográficos
Autores principales: Lozano, Anthony, Souche, Francois-Régis, Chavey, Carine, Dardalhon, Valérie, Ramirez, Christel, Vegna, Serena, Desandre, Guillaume, Riviere, Anaïs, Zine El Aabidine, Amal, Fort, Philippe, Akkari, Leila, Hibner, Urszula, Grégoire, Damien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891719/
https://www.ncbi.nlm.nih.gov/pubmed/36656749
http://dx.doi.org/10.7554/eLife.76294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891719/
https://www.ncbi.nlm.nih.gov/pubmed/36656749
http://dx.doi.org/10.7554/eLife.76294

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