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Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma
Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell fates being driven by signal intensity. We have used primary hepatocy...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891719/ https://www.ncbi.nlm.nih.gov/pubmed/36656749 http://dx.doi.org/10.7554/eLife.76294 |