Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases

OBJECTIVE: Anti-Ro60 and anti-Ro52 antibodies are associated with different connective tissue diseases (CTDs). However, the clinical significance of anti-Ro antibodies is not always consistent among different global regions. The aim of this study was to investigate the clinical characteristics of pa...

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Autores principales: Yang, Hai-Tao, Hong, Xiao-Ping, Guo, Jie-Wen, Zhong, Xiao-Ling, Liao, Rui, Liu, Cui-Lian, Liu, Li-Xiong, Li, Kai, Chen, Yu-Lan, Liu, Dong-Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891828/
https://www.ncbi.nlm.nih.gov/pubmed/36741231
http://dx.doi.org/10.1155/2023/9195157
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author Yang, Hai-Tao
Hong, Xiao-Ping
Guo, Jie-Wen
Zhong, Xiao-Ling
Liao, Rui
Liu, Cui-Lian
Liu, Li-Xiong
Li, Kai
Chen, Yu-Lan
Liu, Dong-Zhou
author_facet Yang, Hai-Tao
Hong, Xiao-Ping
Guo, Jie-Wen
Zhong, Xiao-Ling
Liao, Rui
Liu, Cui-Lian
Liu, Li-Xiong
Li, Kai
Chen, Yu-Lan
Liu, Dong-Zhou
author_sort Yang, Hai-Tao
collection PubMed
description OBJECTIVE: Anti-Ro60 and anti-Ro52 antibodies are associated with different connective tissue diseases (CTDs). However, the clinical significance of anti-Ro antibodies is not always consistent among different global regions. The aim of this study was to investigate the clinical characteristics of patients with anti-Ro antibodies. METHODS: A total of 1596 inpatients with anti-Ro antibodies were included in the study. Demographic, clinical, and serological data were compared between individuals with different profiles of anti-Ro antibodies: patients with anti-Ro52 antibodies alone, patients with anti-Ro60 antibodies alone, and patients with combined anti-Ro52 and anti-Ro60 antibodies. RESULTS: Of the 1596 patients, 1362 (85.3%) were female, the mean age was 45.5 years, and systemic lupus erythematosus (SLE) (46.0%) and Sjogren's syndrome (SS) (19.0%) were the most common CTD diagnoses. Among the patients with anti-Ro52 antibodies alone, idiopathic inflammatory myopathy (18.8%) and SLE (17.6%) were the most common CTD diagnoses. The coexistent autoantibodies of this group were significantly lower compared with those of the other two groups, while the presence of anti-Jo1 antibodies were significantly higher compared with those of the other two groups (3.7% vs. 0.6% vs. 1.9%, p = 0.029). In addition, the patients with isolated anti-Ro52 antibodies were more likely to suffer from interstitial lung disease (35.5% vs. 11.3% vs. 13.7%, p < 10(−4)) and pulmonary arterial hypertension (10.1% vs. 5.3% vs. 3.6%, p = 0.001) compared with the other two groups of patients. Compared with patients with isolated anti-Ro52 or anti-Ro60 antibodies, the patients with combined anti-Ro52 and anti-Ro60 antibodies were more likely to suffer from xerophthalmia and xerostomia. Furthermore, hypocomplementemia, hyperglobulinemia, and proteinuria were particularly prevalent in patients with anti-Ro60 antibodies. CONCLUSION: Different profiles of anti-Ro antibodies were significantly associated with clinical phenotypic features in CTDs, indicating the potential diagnostic and prognostic value of these antibodies in clinical practice.
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spelling pubmed-98918282023-02-02 Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases Yang, Hai-Tao Hong, Xiao-Ping Guo, Jie-Wen Zhong, Xiao-Ling Liao, Rui Liu, Cui-Lian Liu, Li-Xiong Li, Kai Chen, Yu-Lan Liu, Dong-Zhou J Immunol Res Research Article OBJECTIVE: Anti-Ro60 and anti-Ro52 antibodies are associated with different connective tissue diseases (CTDs). However, the clinical significance of anti-Ro antibodies is not always consistent among different global regions. The aim of this study was to investigate the clinical characteristics of patients with anti-Ro antibodies. METHODS: A total of 1596 inpatients with anti-Ro antibodies were included in the study. Demographic, clinical, and serological data were compared between individuals with different profiles of anti-Ro antibodies: patients with anti-Ro52 antibodies alone, patients with anti-Ro60 antibodies alone, and patients with combined anti-Ro52 and anti-Ro60 antibodies. RESULTS: Of the 1596 patients, 1362 (85.3%) were female, the mean age was 45.5 years, and systemic lupus erythematosus (SLE) (46.0%) and Sjogren's syndrome (SS) (19.0%) were the most common CTD diagnoses. Among the patients with anti-Ro52 antibodies alone, idiopathic inflammatory myopathy (18.8%) and SLE (17.6%) were the most common CTD diagnoses. The coexistent autoantibodies of this group were significantly lower compared with those of the other two groups, while the presence of anti-Jo1 antibodies were significantly higher compared with those of the other two groups (3.7% vs. 0.6% vs. 1.9%, p = 0.029). In addition, the patients with isolated anti-Ro52 antibodies were more likely to suffer from interstitial lung disease (35.5% vs. 11.3% vs. 13.7%, p < 10(−4)) and pulmonary arterial hypertension (10.1% vs. 5.3% vs. 3.6%, p = 0.001) compared with the other two groups of patients. Compared with patients with isolated anti-Ro52 or anti-Ro60 antibodies, the patients with combined anti-Ro52 and anti-Ro60 antibodies were more likely to suffer from xerophthalmia and xerostomia. Furthermore, hypocomplementemia, hyperglobulinemia, and proteinuria were particularly prevalent in patients with anti-Ro60 antibodies. CONCLUSION: Different profiles of anti-Ro antibodies were significantly associated with clinical phenotypic features in CTDs, indicating the potential diagnostic and prognostic value of these antibodies in clinical practice. Hindawi 2023-01-25 /pmc/articles/PMC9891828/ /pubmed/36741231 http://dx.doi.org/10.1155/2023/9195157 Text en Copyright © 2023 Hai-Tao Yang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Hai-Tao
Hong, Xiao-Ping
Guo, Jie-Wen
Zhong, Xiao-Ling
Liao, Rui
Liu, Cui-Lian
Liu, Li-Xiong
Li, Kai
Chen, Yu-Lan
Liu, Dong-Zhou
Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
title Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
title_full Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
title_fullStr Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
title_full_unstemmed Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
title_short Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
title_sort clinical significance of different profiles of anti-ro antibodies in connective tissue diseases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891828/
https://www.ncbi.nlm.nih.gov/pubmed/36741231
http://dx.doi.org/10.1155/2023/9195157
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