Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases
OBJECTIVE: Anti-Ro60 and anti-Ro52 antibodies are associated with different connective tissue diseases (CTDs). However, the clinical significance of anti-Ro antibodies is not always consistent among different global regions. The aim of this study was to investigate the clinical characteristics of pa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891828/ https://www.ncbi.nlm.nih.gov/pubmed/36741231 http://dx.doi.org/10.1155/2023/9195157 |
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author | Yang, Hai-Tao Hong, Xiao-Ping Guo, Jie-Wen Zhong, Xiao-Ling Liao, Rui Liu, Cui-Lian Liu, Li-Xiong Li, Kai Chen, Yu-Lan Liu, Dong-Zhou |
author_facet | Yang, Hai-Tao Hong, Xiao-Ping Guo, Jie-Wen Zhong, Xiao-Ling Liao, Rui Liu, Cui-Lian Liu, Li-Xiong Li, Kai Chen, Yu-Lan Liu, Dong-Zhou |
author_sort | Yang, Hai-Tao |
collection | PubMed |
description | OBJECTIVE: Anti-Ro60 and anti-Ro52 antibodies are associated with different connective tissue diseases (CTDs). However, the clinical significance of anti-Ro antibodies is not always consistent among different global regions. The aim of this study was to investigate the clinical characteristics of patients with anti-Ro antibodies. METHODS: A total of 1596 inpatients with anti-Ro antibodies were included in the study. Demographic, clinical, and serological data were compared between individuals with different profiles of anti-Ro antibodies: patients with anti-Ro52 antibodies alone, patients with anti-Ro60 antibodies alone, and patients with combined anti-Ro52 and anti-Ro60 antibodies. RESULTS: Of the 1596 patients, 1362 (85.3%) were female, the mean age was 45.5 years, and systemic lupus erythematosus (SLE) (46.0%) and Sjogren's syndrome (SS) (19.0%) were the most common CTD diagnoses. Among the patients with anti-Ro52 antibodies alone, idiopathic inflammatory myopathy (18.8%) and SLE (17.6%) were the most common CTD diagnoses. The coexistent autoantibodies of this group were significantly lower compared with those of the other two groups, while the presence of anti-Jo1 antibodies were significantly higher compared with those of the other two groups (3.7% vs. 0.6% vs. 1.9%, p = 0.029). In addition, the patients with isolated anti-Ro52 antibodies were more likely to suffer from interstitial lung disease (35.5% vs. 11.3% vs. 13.7%, p < 10(−4)) and pulmonary arterial hypertension (10.1% vs. 5.3% vs. 3.6%, p = 0.001) compared with the other two groups of patients. Compared with patients with isolated anti-Ro52 or anti-Ro60 antibodies, the patients with combined anti-Ro52 and anti-Ro60 antibodies were more likely to suffer from xerophthalmia and xerostomia. Furthermore, hypocomplementemia, hyperglobulinemia, and proteinuria were particularly prevalent in patients with anti-Ro60 antibodies. CONCLUSION: Different profiles of anti-Ro antibodies were significantly associated with clinical phenotypic features in CTDs, indicating the potential diagnostic and prognostic value of these antibodies in clinical practice. |
format | Online Article Text |
id | pubmed-9891828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-98918282023-02-02 Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases Yang, Hai-Tao Hong, Xiao-Ping Guo, Jie-Wen Zhong, Xiao-Ling Liao, Rui Liu, Cui-Lian Liu, Li-Xiong Li, Kai Chen, Yu-Lan Liu, Dong-Zhou J Immunol Res Research Article OBJECTIVE: Anti-Ro60 and anti-Ro52 antibodies are associated with different connective tissue diseases (CTDs). However, the clinical significance of anti-Ro antibodies is not always consistent among different global regions. The aim of this study was to investigate the clinical characteristics of patients with anti-Ro antibodies. METHODS: A total of 1596 inpatients with anti-Ro antibodies were included in the study. Demographic, clinical, and serological data were compared between individuals with different profiles of anti-Ro antibodies: patients with anti-Ro52 antibodies alone, patients with anti-Ro60 antibodies alone, and patients with combined anti-Ro52 and anti-Ro60 antibodies. RESULTS: Of the 1596 patients, 1362 (85.3%) were female, the mean age was 45.5 years, and systemic lupus erythematosus (SLE) (46.0%) and Sjogren's syndrome (SS) (19.0%) were the most common CTD diagnoses. Among the patients with anti-Ro52 antibodies alone, idiopathic inflammatory myopathy (18.8%) and SLE (17.6%) were the most common CTD diagnoses. The coexistent autoantibodies of this group were significantly lower compared with those of the other two groups, while the presence of anti-Jo1 antibodies were significantly higher compared with those of the other two groups (3.7% vs. 0.6% vs. 1.9%, p = 0.029). In addition, the patients with isolated anti-Ro52 antibodies were more likely to suffer from interstitial lung disease (35.5% vs. 11.3% vs. 13.7%, p < 10(−4)) and pulmonary arterial hypertension (10.1% vs. 5.3% vs. 3.6%, p = 0.001) compared with the other two groups of patients. Compared with patients with isolated anti-Ro52 or anti-Ro60 antibodies, the patients with combined anti-Ro52 and anti-Ro60 antibodies were more likely to suffer from xerophthalmia and xerostomia. Furthermore, hypocomplementemia, hyperglobulinemia, and proteinuria were particularly prevalent in patients with anti-Ro60 antibodies. CONCLUSION: Different profiles of anti-Ro antibodies were significantly associated with clinical phenotypic features in CTDs, indicating the potential diagnostic and prognostic value of these antibodies in clinical practice. Hindawi 2023-01-25 /pmc/articles/PMC9891828/ /pubmed/36741231 http://dx.doi.org/10.1155/2023/9195157 Text en Copyright © 2023 Hai-Tao Yang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Hai-Tao Hong, Xiao-Ping Guo, Jie-Wen Zhong, Xiao-Ling Liao, Rui Liu, Cui-Lian Liu, Li-Xiong Li, Kai Chen, Yu-Lan Liu, Dong-Zhou Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases |
title | Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases |
title_full | Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases |
title_fullStr | Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases |
title_full_unstemmed | Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases |
title_short | Clinical Significance of Different Profiles of anti-Ro Antibodies in Connective Tissue Diseases |
title_sort | clinical significance of different profiles of anti-ro antibodies in connective tissue diseases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891828/ https://www.ncbi.nlm.nih.gov/pubmed/36741231 http://dx.doi.org/10.1155/2023/9195157 |
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