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Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A

The quickly accumulating ribosome profiling data is an insightful resource for studying the critical details of translation regulation under various biological contexts. Rocaglamide A (RocA), an antitumor heterotricyclic natural compound, has been shown to inhibit translation initiation of a large g...

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Detalles Bibliográficos
Autores principales: Li, Fajin, Fang, Jianhuo, Yu, Yifan, Hao, Sijia, Zou, Qin, Zeng, Qinglin, Yang, Xuerui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891901/
https://www.ncbi.nlm.nih.gov/pubmed/36725859
http://dx.doi.org/10.1038/s41467-023-36290-w