Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

BACKGROUND: Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal muscle accelerates sarcopenia development in adult mice. Con...

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Detalles Bibliográficos
Autores principales: Crombie, Elisa M., Kim, Seonyoung, Adamson, Stuart, Dong, Han, Lu, Tzu‐Chiao, Wu, Yiju, Wu, Yajun, Levy, Yotam, Stimple, Nolan, Lam, Wing Moon R., Hey, Hwee Weng D., Withers, Dominic J., Hsu, Ao‐Lin, Bay, Boon Huat, Ochala, Julien, Tsai, Shih‐Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891956/
https://www.ncbi.nlm.nih.gov/pubmed/36398408
http://dx.doi.org/10.1002/jcsm.13121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891956/
https://www.ncbi.nlm.nih.gov/pubmed/36398408
http://dx.doi.org/10.1002/jcsm.13121

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