Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications

Balancing natural selection is a process by which genetic variants arise in populations that are beneficial to heterozygous carriers, but pathogenic when homozygous. We systematically investigated the prevalence, structural, and functional consequences of pathogenic IL10RA variants that are associat...

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Detalles Bibliográficos
Autores principales: Aschenbrenner, Dominik, Ye, Ziqing, Zhou, Ying, Hu, Wenhui, Brooks, Isabel, Williams, Isabelle, Capitani, Melania, Gartner, Lisa, Kotlarz, Daniel, Snapper, Scott B., Klein, Christoph, Muise, Aleixo M., Marsden, Brian D., Huang, Ying, Uhlig, Holm H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892166/
https://www.ncbi.nlm.nih.gov/pubmed/36370291
http://dx.doi.org/10.1007/s10875-022-01366-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892166/
https://www.ncbi.nlm.nih.gov/pubmed/36370291
http://dx.doi.org/10.1007/s10875-022-01366-7

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