A split ribozyme that links detection of a native RNA to orthogonal protein outputs

Individual RNA remains a challenging signal to synthetically transduce into different types of cellular information. Here, we describe Ribozyme-ENabled Detection of RNA (RENDR), a plug-and-play strategy that uses cellular transcripts to template the assembly of split ribozymes, triggering splicing r...

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Detalles Bibliográficos
Autores principales: Gambill, Lauren, Staubus, August, Mo, Kim Wai, Ameruoso, Andrea, Chappell, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892565/
https://www.ncbi.nlm.nih.gov/pubmed/36725852
http://dx.doi.org/10.1038/s41467-023-36073-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892565/
https://www.ncbi.nlm.nih.gov/pubmed/36725852
http://dx.doi.org/10.1038/s41467-023-36073-3

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