Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer’s disease: An integrative molecular modeling approach

Alzheimer’s disease (AD) is a neurological disorder caused by the abnormal accumulation of hyperphosphorylated proteins. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dual phosphorylation enzyme which phosphorylates the amyloid-β (Aβ) and neurofibrillary tangles (NFTs)....

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Detalles Bibliográficos
Autores principales: Shukla, Rohit, Kumar, Anuj, Kelvin, David J., Singh, Tiratha Raj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892649/
https://www.ncbi.nlm.nih.gov/pubmed/36741918
http://dx.doi.org/10.3389/fmolb.2022.1078987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892649/
https://www.ncbi.nlm.nih.gov/pubmed/36741918
http://dx.doi.org/10.3389/fmolb.2022.1078987

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