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CpH methylome analysis in human cortical neurons identifies novel gene pathways and drug targets for opioid use disorder

INTRODUCTION: DNA methylation (DNAm), an epigenetic mechanism, has been associated with opioid use disorder (OUD) in preclinical and human studies. However, most of the studies have focused on DNAm at CpG sites. DNAm at non-CpG sites (mCpHs, where H indicates A, T, or C) has been recently shown to h...

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Detalles Bibliográficos
Autores principales: Nagamatsu, Sheila T., Rompala, Gregory, Hurd, Yasmin L., Núñez-Rios, Diana L., Montalvo-Ortiz, Janitza L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892724/
https://www.ncbi.nlm.nih.gov/pubmed/36745154
http://dx.doi.org/10.3389/fpsyt.2022.1078894