Non-phosphorylatable mutants of Ser184 lead to incomplete activation of Bax

The S184 residue of Bax is the target of several protein kinases regulating cell fate, including AKT. It is well-established that, in cellulo, the substitution of S184 by a non-phosphorylatable residue stimulates both the mitochondrial localization of Bax, cytochrome c release, and apoptosis. Howeve...

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Detalles Bibliográficos
Autores principales: Simonyan, Lilit, Gonin, Mathilde, Hanks, James, Friedlein, Jordan, Dutrec, Kevin, Arokium, Hubert, Rouchidane Eyitayo, Akandé, Doudy, Toukounou Megann, Chaignepain, Stéphane, Manon, Stéphen, Dejean, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892840/
https://www.ncbi.nlm.nih.gov/pubmed/36741728
http://dx.doi.org/10.3389/fonc.2022.1068994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892840/
https://www.ncbi.nlm.nih.gov/pubmed/36741728
http://dx.doi.org/10.3389/fonc.2022.1068994

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