A chemical screen underscores the essential role of STAT1-dependent IFNγ signaling to regulate HLA-I expression in cancer cells

The presentation of neoantigens by HLA-I is essential for the recognition of tumor cells by cytotoxic T cells. Transcriptionally, HLA-I expression is regulated by interferon-dependent activation of JAK/STAT signaling. Accordingly, mutations that inactivate this pathway are one of the main causes of...

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Detalles Bibliográficos
Autores principales: Barz, Myriam, Porebski, Bartlomiej, Panshikar, Pranauti, Häggbladd, Maria, Hühn, Daniela, Fernandez-Capetillo, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892930/
https://www.ncbi.nlm.nih.gov/pubmed/36743451
http://dx.doi.org/10.17912/micropub.biology.000697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892930/
https://www.ncbi.nlm.nih.gov/pubmed/36743451
http://dx.doi.org/10.17912/micropub.biology.000697

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