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Memantine as a neuroprotective agent in ischemic stroke: Preclinical and clinical analysis
The primary mechanism for neuron death after an ischemic stroke is excitotoxic injury. Excessive depolarization leads to NMDA-mediated calcium entry to the neuron and, subsequently, cellular death. Therefore, the inhibition of the NMDA channel has been proposed as a neuroprotective measure in ischem...
Autores principales: | Pichardo-Rojas, Diego, Pichardo-Rojas, Pavel Salvador, Cornejo-Bravo, José Manuel, Serrano-Medina, Aracely |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893121/ https://www.ncbi.nlm.nih.gov/pubmed/36743806 http://dx.doi.org/10.3389/fnins.2023.1096372 |
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