Downregulation of the Autism Spectrum Disorder Gene Shank2 Decreases Bone Mass in Male Mice

Mutations of the postsynaptic scaffold protein Shank2 lead to autism spectrum disorders (ASD). These patients frequently suffer from higher fracture risk. Here, we investigated whether Shank2 directly regulates bone mass. We show that Shank2 is expressed in bone and that Shank2 levels are increased...

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Detalles Bibliográficos
Autores principales: Ahmad, Mubashir, Stirmlinger, Nadine, Jan, Irfana, Stifel, Ulrich, Lee, Sooyeon, Weingandt, Marcel, Kelp, Ulrike, Bockmann, Jürgen, Ignatius, Anita, Böckers, Tobias M., Tuckermann, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893268/
https://www.ncbi.nlm.nih.gov/pubmed/36751416
http://dx.doi.org/10.1002/jbm4.10711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893268/
https://www.ncbi.nlm.nih.gov/pubmed/36751416
http://dx.doi.org/10.1002/jbm4.10711

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