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Pulse labeling reveals the tail end of protein folding by proteome profiling

Accurate and efficient folding of nascent protein sequences into their native states requires support from the protein homeostasis network. Herein we probe which newly translated proteins are thermo-sensitive, making them susceptible to misfolding and aggregation under heat stress using pulse-SILAC...

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Detalles Bibliográficos
Autores principales: Zhu, Mang, Kuechler, Erich R., Wong, Ryan W.K., Calabrese, Gaetano, Sitarik, Ian M., Rana, Viraj, Stoynov, Nikolay, O’Brien, Edward P., Gsponer, Jörg, Mayor, Thibault
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9893312/
https://www.ncbi.nlm.nih.gov/pubmed/35858568
http://dx.doi.org/10.1016/j.celrep.2022.111096