Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors

Activation of endogenous retrotransposons frequently occurs in cancer cells and contributes to tumor genomic instability. To test whether inhibition of retrotranspositions has an anticancer effect, we used treatment with the nucleoside reverse transcriptase inhibitor (NRTI) stavudine (STV) in mouse...

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Detalles Bibliográficos
Autores principales: Novototskaya-Vlasova, Ksenia A., Neznanov, Nickolay S., Molodtsov, Ivan, Hall, Brandon M., Commane, Mairead, Gleiberman, Anatoli S., Murray, Jayne, Haber, Michelle, Norris, Murray D., Leonova, Katerina I., Gudkov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894111/
https://www.ncbi.nlm.nih.gov/pubmed/36449545
http://dx.doi.org/10.1073/pnas.2213146119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894111/
https://www.ncbi.nlm.nih.gov/pubmed/36449545
http://dx.doi.org/10.1073/pnas.2213146119

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