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In silico identification of a β(2)-adrenoceptor allosteric site that selectively augments canonical β(2)AR-Gs signaling and function
Activation of β(2)-adrenoceptors (β(2)ARs) causes airway smooth muscle (ASM) relaxation and bronchodilation, and β(2)AR agonists (β-agonists) are front-line treatments for asthma and other obstructive lung diseases. However, the therapeutic efficacy of β-agonists is limited by agonist-induced β(2)AR...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894167/ https://www.ncbi.nlm.nih.gov/pubmed/36449547 http://dx.doi.org/10.1073/pnas.2214024119 |