Stochastic survival of the densest and mitochondrial DNA clonal expansion in aging

The expansion of mitochondrial DNA molecules with deletions has been associated with aging, particularly in skeletal muscle fibers; its mechanism has remained unclear for three decades. Previous accounts have assigned a replicative advantage (RA) to mitochondrial DNA containing deletion mutations, b...

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Detalles Bibliográficos
Autores principales: Insalata, Ferdinando, Hoitzing, Hanne, Aryaman, Juvid, Jones, Nick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894218/
https://www.ncbi.nlm.nih.gov/pubmed/36442091
http://dx.doi.org/10.1073/pnas.2122073119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894218/
https://www.ncbi.nlm.nih.gov/pubmed/36442091
http://dx.doi.org/10.1073/pnas.2122073119

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