Early diagnosis and treatment of Alzheimer’s disease by targeting toxic soluble Aβ oligomers

Transient soluble oligomers of amyloid-β (Aβ) are toxic and accumulate early prior to insoluble plaque formation and cognitive impairment in Alzheimer’s disease (AD). Synthetic cyclic D,L-α-peptides (e.g., 1) self-assemble into cross β-sheet nanotubes, react with early Aβ species (1-3 mers), and inh...

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Detalles Bibliográficos
Autores principales: Habashi, Maram, Vutla, Suresh, Tripathi, Kuldeep, Senapati, Sudipta, Chauhan, Pradeep S., Haviv-Chesner, Anat, Richman, Michal, Mohand, Samia-Ait, Dumulon-Perreault, Véronique, Mulamreddy, Ramakotaiah, Okun, Eitan, Chill, Jordan H., Guérin, Brigitte, Lubell, William D., Rahimipour, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894226/
https://www.ncbi.nlm.nih.gov/pubmed/36442093
http://dx.doi.org/10.1073/pnas.2210766119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894226/
https://www.ncbi.nlm.nih.gov/pubmed/36442093
http://dx.doi.org/10.1073/pnas.2210766119

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