Decorating chromatin for enhanced genome editing using CRISPR-Cas9

CRISPR-associated (Cas) enzymes have revolutionized biology by enabling RNA-guided genome editing. Homology-directed repair (HDR) in the presence of donor templates is currently the most versatile method to introduce precise edits following CRISPR-Cas-induced double-stranded DNA cuts, but HDR effici...

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Detalles Bibliográficos
Autores principales: Chen, Evelyn, Lin-Shiao, Enrique, Trinidad, Marena, Saffari Doost, Mohammad, Colognori, David, Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894255/
https://www.ncbi.nlm.nih.gov/pubmed/36459645
http://dx.doi.org/10.1073/pnas.2204259119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894255/
https://www.ncbi.nlm.nih.gov/pubmed/36459645
http://dx.doi.org/10.1073/pnas.2204259119

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