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Decorating chromatin for enhanced genome editing using CRISPR-Cas9

CRISPR-associated (Cas) enzymes have revolutionized biology by enabling RNA-guided genome editing. Homology-directed repair (HDR) in the presence of donor templates is currently the most versatile method to introduce precise edits following CRISPR-Cas-induced double-stranded DNA cuts, but HDR effici...

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Detalles Bibliográficos
Autores principales:	Chen, Evelyn, Lin-Shiao, Enrique, Trinidad, Marena, Saffari Doost, Mohammad, Colognori, David, Doudna, Jennifer A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894255/ https://www.ncbi.nlm.nih.gov/pubmed/36459645 http://dx.doi.org/10.1073/pnas.2204259119

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