Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel

Gemcitabine is an antineoplastic drug commonly used in the treatment of several types of cancers including pancreatic cancer and non–small cell lung cancer. Although gemcitabine-induced cardiotoxicity is widely recognized, the exact mechanism of cardiac dysfunction causing arrhythmias remains unclea...

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Detalles Bibliográficos
Autores principales: Wei, Mengyan, Wang, Pu, Zhu, Xiufang, Morishima, Masaki, Liu, Yangong, Zheng, Mingqi, Liu, Gang, Osanai, Hiroki, Yoshimura, Kenshi, Kume, Shinichiro, Kurokawa, Tatsuki, Ono, Katsushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894456/
https://www.ncbi.nlm.nih.gov/pubmed/36730356
http://dx.doi.org/10.1371/journal.pone.0280656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894456/
https://www.ncbi.nlm.nih.gov/pubmed/36730356
http://dx.doi.org/10.1371/journal.pone.0280656

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