Exploring novel fluorine-rich fuberidazole derivatives as hypoxic cancer inhibitors: Design, synthesis, pharmacokinetics, molecular docking, and DFT evaluations

Sixteen fuberidazole derivatives as potential new anticancer bioreductive prodrugs were prepared and characterized. The in vitro anticancer potential was examined to explore their cytotoxic properties by employing apoptosis, DNA damage, and proliferation tests on chosen hypoxic cancer cells. Eight s...

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Detalles Bibliográficos
Autores principales: Taj, Muhammad Babar, Raheel, Ahmad, Ayub, Rabia, Alnajeebi, Afnan M., Abualnaja, Matokah, Habib, Alaa Hamed, Alelwani, Walla, Noor, Sadia, Ullah, Sami, Al-Sehemi, Abdullah G., Simsek, Rahime, Babteen, Nouf Abubakr, Alshater, Heba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894469/
https://www.ncbi.nlm.nih.gov/pubmed/36730213
http://dx.doi.org/10.1371/journal.pone.0262790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894469/
https://www.ncbi.nlm.nih.gov/pubmed/36730213
http://dx.doi.org/10.1371/journal.pone.0262790

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