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Synaptogenic effect of APP-Swedish mutation in familial Alzheimer’s disease

Mutations in β-amyloid (Aβ) precursor protein (APP) cause familial Alzheimer’s disease (AD) probably by enhancing Aβ peptides production from APP. An antibody targeting Aβ (aducanumab) was approved as an AD treatment; however, some Aβ antibodies have been reported to accelerate, instead of ameliorat...

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Detalles Bibliográficos
Autores principales: Zhou, Bo, Lu, Jacqueline G., Siddu, Alberto, Wernig, Marius, Südhof, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894682/
https://www.ncbi.nlm.nih.gov/pubmed/36260691
http://dx.doi.org/10.1126/scitranslmed.abn9380