PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation

Cytosine hypermethylation in and around DNA-binding sites of master transcription factors, including PU.1, occurs in aging hematopoietic stem cells following acquired loss-of-function mutations of DNA methyl-cytosine dioxygenase ten–eleven translocation-2 (TET2), albeit functional relevance has been...

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Detalles Bibliográficos
Autores principales: Aivalioti, Maria M., Bartholdy, Boris A., Pradhan, Kith, Bhagat, Tushar D., Zintiridou, Aliona, Jeong, Jong Jin, Thiruthuvanathan, Victor J., Pujato, Mario, Paranjpe, Aditi, Zhang, Chi, Levine, Ross L., Viny, Aaron D., Wickrema, Amittha, Verma, Amit, Will, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894728/
https://www.ncbi.nlm.nih.gov/pubmed/35820129
http://dx.doi.org/10.1158/2643-3230.BCD-21-0226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894728/
https://www.ncbi.nlm.nih.gov/pubmed/35820129
http://dx.doi.org/10.1158/2643-3230.BCD-21-0226

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