Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α

P110α is a member of the phosphoinositide 3-kinase (PI3K) enzyme family that functions downstream of RAS. RAS proteins contribute to the activation of p110α by interacting directly with its RAS binding domain (RBD), resulting in the promotion of many cellular functions such as cell growth, prolifera...

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Detalles Bibliográficos
Autores principales: Ismail, Mohamed, Martin, Stephen R., George, Roger, Houghton, Francesca, Kelly, Geoff, Chaleil, Raphaël A. G., Anastasiou, Panayiotis, Wang, Xinyue, O’Reilly, Nicola, Federico, Stefania, Joshi, Dhira, Nagaraj, Hemavathi, Cooley, Rachel, Hui, Ning Sze, Molina-Arcas, Miriam, Hancock, David C., Tavassoli, Ali, Downward, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894841/
https://www.ncbi.nlm.nih.gov/pubmed/36732563
http://dx.doi.org/10.1038/s41598-023-28756-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894841/
https://www.ncbi.nlm.nih.gov/pubmed/36732563
http://dx.doi.org/10.1038/s41598-023-28756-0

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