Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells

Adeno-associated viral (AAV) vector suspensions produced in either human derived HEK cells or in Spodoptera frugiperda (Sf9) insect cells differ in terms of residual host cell components as well as species-specific post-translational modifications displayed on the AAV capsid proteins. Here we analys...

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Detalles Bibliográficos
Autores principales: Bucher, Kirsten, Rodríguez-Bocanegra, Eduardo, Wissinger, Bernd, Strasser, Torsten, Clark, Simon J., Birkenfeld, Andreas L., Siegel-Axel, Dorothea, Fischer, M. Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894911/
https://www.ncbi.nlm.nih.gov/pubmed/36732401
http://dx.doi.org/10.1038/s41598-023-28830-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9894911/
https://www.ncbi.nlm.nih.gov/pubmed/36732401
http://dx.doi.org/10.1038/s41598-023-28830-7

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