Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure

Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and correlates with T2D progression. However, it is unknown whether ALDH1A3 activity contributes to β-cell failure, and whether the decrease of ALD...

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Detalles Bibliográficos
Autores principales: Son, Jinsook, Du, Wen, Esposito, Mark, Shariati, Kaavian, Ding, Hongxu, Kang, Yibin, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895451/
https://www.ncbi.nlm.nih.gov/pubmed/36732513
http://dx.doi.org/10.1038/s41467-023-36315-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895451/
https://www.ncbi.nlm.nih.gov/pubmed/36732513
http://dx.doi.org/10.1038/s41467-023-36315-4

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