Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection

To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and lineage choices are dependent on spatial context and c...

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Detalles Bibliográficos
Autores principales: Heimli, Marte, Flåm, Siri Tennebø, Hjorthaug, Hanne Sagsveen, Trinh, Don, Frisk, Michael, Dumont, Karl-Andreas, Ribarska, Teodora, Tekpli, Xavier, Saare, Mario, Lie, Benedicte Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895842/
https://www.ncbi.nlm.nih.gov/pubmed/36741401
http://dx.doi.org/10.3389/fimmu.2022.1092028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895842/
https://www.ncbi.nlm.nih.gov/pubmed/36741401
http://dx.doi.org/10.3389/fimmu.2022.1092028

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