Cargando…
Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and lineage choices are dependent on spatial context and c...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895842/ https://www.ncbi.nlm.nih.gov/pubmed/36741401 http://dx.doi.org/10.3389/fimmu.2022.1092028 |