Cargando…
Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti–PD-1 and Anti–PD-L1 Treatment in a Checkpoint Refractory Melanoma Model
Extracellular vesicles (EV) are important mediators of intercellular communication and are potential candidates for cancer immunotherapy. Immune checkpoint blockade, specifically targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) axis, mitigates T-cell exhaustion,...
Autores principales: | Veerman, Rosanne E., Akpinar, Gözde Güclüler, Offens, Annemarijn, Steiner, Loïc, Larssen, Pia, Lundqvist, Andreas, Karlsson, Mikael C.I., Gabrielsson, Susanne |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896027/ https://www.ncbi.nlm.nih.gov/pubmed/36546872 http://dx.doi.org/10.1158/2326-6066.CIR-22-0540 |
Ejemplares similares
-
Exosomes from antigen-pulsed dendritic cells induce stronger antigen-specific immune responses than microvesicles in vivo
por: Wahlund, Casper J. E., et al.
Publicado: (2017) -
Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin
por: Veerman, Rosanne E., et al.
Publicado: (2021) -
Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?
por: O’Donnell, Jake S., et al.
Publicado: (2016) -
Efficacy and Safety of PD-1/PD-L1 Checkpoint Inhibitors versus Anti-PD-1/PD-L1 Combined with Other Therapies for Tumors: A Systematic Review
por: Zhang, Yiru, et al.
Publicado: (2023) -
Seeing is believing: anti-PD-1/PD-L1 monoclonal antibodies in action for checkpoint blockade tumor immunotherapy
por: Tan, Shuguang, et al.
Publicado: (2016)