Cargando…

Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons

The aim of this work was to monitor the effects of extracellular α-synuclein on the firing activity of midbrain neurons dissociated from substantia nigra TH-GFP mice embryos and cultured on microelectrode arrays (MEA). We monitored the spontaneous firing discharge of the network for 21 days after pl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomagra, Giulia, Franchino, Claudio, Cesano, Federico, Chiarion, Giovanni, de lure, Antonio, Carbone, Emilio, Calabresi, Paolo, Mesin, Luca, Picconi, Barbara, Marcantoni, Andrea, Carabelli, Valentina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896582/ https://www.ncbi.nlm.nih.gov/pubmed/36744002 http://dx.doi.org/10.3389/fncel.2023.1078550

Ejemplares similares

Corrigendum: Alpha-synuclein oligomers alter the spontaneous firing discharge of cultured midbrain neurons
por: Tomagra, Giulia, et al.
Publicado: (2023)

Quantal Release of Dopamine and Action Potential Firing Detected in Midbrain Neurons by Multifunctional Diamond-Based Microarrays
por: Tomagra, Giulia, et al.
Publicado: (2019)

Two firing modes and well-resolved Na(+), K(+), and Ca(2+) currents at the cell-microelectrode junction of spontaneously active rat chromaffin cell on MEAs
por: Marcantoni, Andrea, et al.
Publicado: (2022)

Correction to: Two firing modes and well‑resolved Na(+), K(+), and Ca(2+) currents at the cell‑microelectrode junction of spontaneously active rat chromaffin cell on MEAs
por: Marcantoni, Andrea, et al.
Publicado: (2022)

Leptin Counteracts the Hypoxia-Induced Inhibition of Spontaneously Firing Hippocampal Neurons: A Microelectrode Array Study
por: Gavello, Daniela, et al.
Publicado: (2012)

Lighting Up Alpha-synuclein Oligomers
por: Richter, Franziska
Publicado: (2018)

Direct detection of alpha synuclein oligomers in vivo
por: Dimant, Hemi, et al.
Publicado: (2013)

Alpha-synuclein oligomers: a new hope
por: Bengoa-Vergniory, Nora, et al.
Publicado: (2017)

Nanodiamond–Quantum Sensors Reveal Temperature Variation Associated to Hippocampal Neurons Firing
por: Petrini, Giulia, et al.
Publicado: (2022)

Nanodiamond–Quantum Sensors Reveal Temperature Variation Associated to Hippocampal Neurons Firing
por: Petrini, Giulia, et al.
Publicado: (2023)

Exosomal cell-to-cell transmission of alpha synuclein oligomers
por: Danzer, Karin M, et al.
Publicado: (2012)

Structural and Biophysical Characterization of Stable Alpha-Synuclein Oligomers
por: Vaikath, Nishant, et al.
Publicado: (2022)

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
por: Gustafsson, Gabriel, et al.
Publicado: (2017)

Temperature-Dependent Structural Changes of Parkinson's Alpha-Synuclein Reveal the Role of Pre-Existing Oligomers in Alpha-Synuclein Fibrillization
por: Ariesandi, Winny, et al.
Publicado: (2013)

Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation
por: Lassen, Louise Berkhoudt, et al.
Publicado: (2022)

DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function
por: Plotegher, N., et al.
Publicado: (2017)

Polymorphism in alpha-synuclein oligomers and its implications in toxicity under disease conditions
por: Yoo, Je Min, et al.
Publicado: (2022)

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies
por: Moore, Kenya, et al.
Publicado: (2023)

Alpha-synuclein is strategically positioned for afferent modulation of midbrain dopamine neurons and is essential for cocaine preference
por: Trubetckaia, Olga, et al.
Publicado: (2019)

The Convergence of Alpha-Synuclein, Mitochondrial, and Lysosomal Pathways in Vulnerability of Midbrain Dopaminergic Neurons in Parkinson’s Disease
por: Minakaki, Georgia, et al.
Publicado: (2020)

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration
por: Ghiglieri, Veronica, et al.
Publicado: (2018)

Background firing in the auditory midbrain of the frog
por: Bibikov, N.G.
Publicado: (2017)

The Intranigral Infusion of Human-Alpha Synuclein Oligomers Induces a Cognitive Impairment in Rats Associated with Changes in Neuronal Firing and Neuroinflammation in the Anterior Cingulate Cortex
por: Palmas, Maria Francesca, et al.
Publicado: (2022)

Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson’s Disease
por: Cardinale, Antonella, et al.
Publicado: (2021)

Ca(v)1.3 Channels as Key Regulators of Neuron-Like Firings and Catecholamine Release in Chromaffin Cells
por: Vandael, David H.F., et al.
Publicado: (2015)

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
por: Ingelsson, Martin
Publicado: (2016)

Discrepancy between distribution of alpha-synuclein oligomers and Lewy-related pathology in Parkinson’s disease
por: Sekiya, Hiroaki, et al.
Publicado: (2022)

β2-subunit alternative splicing stabilizes Cav2.3 Ca(2+) channel activity during continuous midbrain dopamine neuron-like activity
por: Siller, Anita, et al.
Publicado: (2022)

Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques
por: Sucunza, Diego, et al.
Publicado: (2021)

Modelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
por: Nübling, Georg Sebastian, et al.
Publicado: (2014)

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain
por: Roberts, Rosalind F., et al.
Publicado: (2015)

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology
por: Wilkaniec, Anna, et al.
Publicado: (2018)

Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let’s talk about the lipids in the room
por: Killinger, Bryan A., et al.
Publicado: (2019)

Alpha-synuclein oligomers and small nerve fiber pathology in skin are potential biomarkers of Parkinson’s disease
por: Vacchi, Elena, et al.
Publicado: (2021)

Advances in understanding the function of alpha-synuclein: implications for Parkinson’s disease
por: Calabresi, Paolo, et al.
Publicado: (2023)

Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits
por: Guarina, L., et al.
Publicado: (2018)

Quantifying Co-Oligomer Formation by α-Synuclein
por: Iljina, Marija, et al.
Publicado: (2018)

The Role of α-Synuclein Oligomers in Parkinson’s Disease
por: Du, Xiao-yu, et al.
Publicado: (2020)

Stabilization of α-synuclein oligomers using formaldehyde
por: Ruesink, Harm, et al.
Publicado: (2019)

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
por: Deas, Emma, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kn7cuuvsfhcf1g8sm2706d7s06