Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning

STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is considered a promising therapeutic anti-cancer strategy. In this work, we used multiple docked poses of STAT3 inhibitors to augment training data f...

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Detalles Bibliográficos
Autores principales: Jaradat, Nour Jamal, Alshaer, Walhan, Hatmal, Mamon, Taha, Mutasem Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896621/
https://www.ncbi.nlm.nih.gov/pubmed/36760267
http://dx.doi.org/10.1039/d2ra07007c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896621/
https://www.ncbi.nlm.nih.gov/pubmed/36760267
http://dx.doi.org/10.1039/d2ra07007c

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