TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer’s disease via TFEB/TFE3 activation

BACKGROUND: The impairment in the autophagy-lysosomal pathway (ALP) and the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration and neuroinflammation in Alzheimer’s disease (AD), a devastating neurodegenerative disorder...

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Detalles Bibliográficos
Autores principales: Lin, Wenjia, Li, Zhao, Liang, Guangfeng, Zhou, Runjin, Zheng, Xiaoyan, Tao, Rongrong, Huo, Qingwei, Su, Chengfu, Li, Min, Xu, Nenggui, Tang, Chunzhi, Song, Ju-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896717/
https://www.ncbi.nlm.nih.gov/pubmed/36732771
http://dx.doi.org/10.1186/s12974-023-02698-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896717/
https://www.ncbi.nlm.nih.gov/pubmed/36732771
http://dx.doi.org/10.1186/s12974-023-02698-w

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